Abstract
Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Colonic Neoplasms / drug therapy
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Colonic Neoplasms / pathology
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Geologic Sediments
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HeLa Cells
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Mycophenolic Acid / analogs & derivatives
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Mycophenolic Acid / chemistry
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Mycophenolic Acid / isolation & purification
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Mycophenolic Acid / pharmacology
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Penicillium / chemistry*
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ortho-Aminobenzoates / chemistry
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ortho-Aminobenzoates / isolation & purification
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ortho-Aminobenzoates / pharmacology*
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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ortho-Aminobenzoates
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penicacid A
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anthranilic acid
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Mycophenolic Acid