There are no commercially available liquid medications that are formulated for feeding tube administration. The goal and indication of orally administered medications formulated in liquids is for pediatric patients or patients with limited ability to swallow tablets. Pharmacists who are considering compounding medications for feeding tube administration must be aware of the many issues involved in preparing drugs for this purpose. Many of these issues are discussed in this article. Also included in this article are reviews of some the literature involving the issues in co-administering nutrition by the same route.