Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

Chem Commun (Camb). 2014 Jan 14;50(4):406-8. doi: 10.1039/c3cc45454a.

Abstract

Trans-activation response DNA-binding protein of 43 kDa (TDP-43), a key factor in several neurodegenerative conditions, was discovered as a novel target of heteronemin by chemical proteomics. Combining bio-physical orthogonal approaches with biological analysis, heteronemin was found to influence the binding of TDP-43-cognate nucleic acids and to modulate the TDP-43 aggregation state and its cellular localization.

MeSH terms

  • Animals
  • DNA, Single-Stranded / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / metabolism*
  • HeLa Cells
  • Humans
  • Microscopy, Confocal
  • NF-kappa B / metabolism
  • Neurodegenerative Diseases / metabolism
  • Neurodegenerative Diseases / pathology
  • Porifera / chemistry*
  • Porifera / metabolism
  • Protein Binding
  • Terpenes / chemistry
  • Terpenes / isolation & purification
  • Terpenes / metabolism*

Substances

  • DNA, Single-Stranded
  • DNA-Binding Proteins
  • NF-kappa B
  • Terpenes
  • heteronemin