Dipyridamole and paracetamol overdose resulting in multi-organ failure

Scott Med J. 2013 Aug;58(3):e14-7. doi: 10.1177/0036933013496926.

Abstract

Dipyridamole intoxication is rare and few reports exist amongst the current literature. A case of dipyridamole and paracetamol overdose is described in a previously healthy 58-year-old woman, which resulted in multi-organ failure requiring dialysis, inotropic support, ventilation and extensive surgical intervention for small bowel ischaemia. This case highlights the dangers of an unusually large overdose of a commonly prescribed drug, and reviews current knowledge of dipyridamole intoxication.

Keywords: Dipyridamole; ischaemic bowel; multi-organ failure; overdose.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Acetaminophen / poisoning*
  • Analgesics, Non-Narcotic / poisoning*
  • Depression / drug therapy
  • Depression / psychology
  • Dipyridamole / poisoning*
  • Drug Overdose / complications*
  • Drug Overdose / physiopathology
  • Drug Overdose / psychology
  • Female
  • Hospitalization
  • Humans
  • Laparotomy
  • Middle Aged
  • Multiple Organ Failure / chemically induced*
  • Multiple Organ Failure / drug therapy
  • Multiple Organ Failure / surgery
  • Parenteral Nutrition, Home
  • Platelet Aggregation Inhibitors / poisoning*
  • Prognosis
  • Renal Dialysis
  • Scotland
  • Suicide, Attempted*
  • Time Factors
  • Treatment Outcome

Substances

  • Analgesics, Non-Narcotic
  • Platelet Aggregation Inhibitors
  • Acetaminophen
  • Dipyridamole