Gold nanoparticles protected by fluorinated ligands for 19F MRI

Chem Commun (Camb). 2013 Oct 9;49(78):8794-6. doi: 10.1039/c3cc44572k.

Abstract

Gold nanoparticles coated with fluorinated ligands (F-MPCs) present features suitable for (19)F MRI as observed from phantom experiments. Cellular uptake, by HeLa cells, and toxicity of fluorescent dye-decorated F-MPCs are presented together with their ability to bind hydrophobic molecules allowing for a potential combination of targeting, delivery and imaging features.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorine Compounds / chemistry*
  • Fluorine Compounds / metabolism
  • Fluorine Compounds / toxicity
  • Gold / chemistry*
  • Gold / metabolism
  • Gold / toxicity
  • Halogenation
  • HeLa Cells
  • Humans
  • Ligands
  • Magnetic Resonance Imaging
  • Models, Molecular
  • Nanoparticles / chemistry*
  • Nanoparticles / metabolism
  • Nanoparticles / toxicity

Substances

  • Fluorine Compounds
  • Ligands
  • Gold