Stupp-treated glioblastoma accompanied by EBV-positive primary CNS lymphoma

Br J Neurosurg. 2014 Apr;28(2):287-9. doi: 10.3109/02688697.2013.829554. Epub 2013 Aug 19.

Abstract

We describe a patient who within 2 months of undergoing radio-chemotherapy for glioblastoma developed an Epstein-Barr virus-positive primary diffuse large B-cell CNS lymphoma. To our knowledge, this is the first such case reported in the literature showing that new tumefactions following aggressive treatment for glioblastomata might represent secondary malignancies.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents, Alkylating / therapeutic use
  • Brain Neoplasms / complications
  • Brain Neoplasms / surgery
  • Brain Neoplasms / therapy*
  • Chemoradiotherapy
  • Clinical Protocols
  • Dacarbazine / analogs & derivatives
  • Dacarbazine / therapeutic use
  • Epstein-Barr Virus Infections / complications*
  • Fatal Outcome
  • Glioblastoma / complications
  • Glioblastoma / surgery
  • Glioblastoma / therapy*
  • Headache / etiology
  • Humans
  • Lymphoma, B-Cell / complications
  • Lymphoma, B-Cell / surgery*
  • Magnetic Resonance Imaging
  • Male
  • Neurosurgical Procedures / methods*
  • Temozolomide
  • Tomography, X-Ray Computed

Substances

  • Antineoplastic Agents, Alkylating
  • Dacarbazine
  • Temozolomide