Abstract
Objective:
To identify novel potential biomarkers and evaluate combined biomarkers for diagnosing kidney injury with considerable accuracy in preeclampsia.
Methods:
The level of serum and urine neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), retinol-binding protein (RBP) and interleukin-18 (IL-18) were measured by enzyme-linked immunosorbent assay.
Results:
The level of serum cystatin C, urine RBP, urine NGAL and urine KIM-1 in preeclampsia group were higher than that in the normal pregnancy group. When four biomarkers are combined, the sensitivity and specificity are 100%/98.20%.
Conclusion:
Urine KIM-1 is the most potential biomarker for renal injury in preeclampsia. The more biomarkers combined, the more sensitivity and specificity were increased.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute-Phase Proteins / urine
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Adult
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Biomarkers / blood
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Biomarkers / urine
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Case-Control Studies
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Cross-Sectional Studies
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Cystatin C / blood
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Female
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Hepatitis A Virus Cellular Receptor 1
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Humans
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Interleukin-18 / blood
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Interleukin-18 / urine
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Lipocalin-2
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Lipocalins / blood
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Lipocalins / urine
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Membrane Glycoproteins / blood
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Membrane Glycoproteins / urine
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Pre-Eclampsia / blood*
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Pre-Eclampsia / urine*
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Pregnancy
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Proto-Oncogene Proteins / blood
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Proto-Oncogene Proteins / urine
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Receptors, Virus / blood
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Renal Insufficiency / diagnosis*
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Renal Insufficiency / etiology*
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Renal Insufficiency / metabolism*
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Retinol-Binding Proteins / urine
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Sensitivity and Specificity
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Young Adult
Substances
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Acute-Phase Proteins
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Biomarkers
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Cystatin C
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HAVCR1 protein, human
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Hepatitis A Virus Cellular Receptor 1
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Interleukin-18
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LCN2 protein, human
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Lipocalin-2
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Lipocalins
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Membrane Glycoproteins
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Proto-Oncogene Proteins
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Receptors, Virus
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Retinol-Binding Proteins