Dancing with diversity: The synthesis of diverse pyrido[2',1':2,3]imidazo[4,5-b]quinolines bearing several substitution patterns was developed based on combining a multicomponent reaction (Groebke-Blackburn-Bienaymé reaction) with an original cyclization as a secondary transformation (see scheme; DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
Keywords: Groebke-Blackburn-Bienaymé reaction; aromatic cyclization; cyclization; diversity-oriented synthesis; multicomponent reactions.
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