Abstract
Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/nesfatin-1 is widely expressed in various peripheral tissues, including those of the gastrointestinal tract where it may participate in various pathophysiological processes. One of its roles may be regulation of energy homeostasis. As a result, nesfatin-1 may be a novel target for exploring the underlying mechanisms and the treatment of metabolic syndromes.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adipose Tissue / innervation
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Adipose Tissue / metabolism*
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Animals
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Appetite Regulation*
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Calcium-Binding Proteins / genetics
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Calcium-Binding Proteins / metabolism*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Energy Metabolism*
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Gastrointestinal Tract / innervation
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Gastrointestinal Tract / metabolism*
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Gene Expression Regulation
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Genetic Predisposition to Disease
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Homeostasis
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Humans
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Metabolic Diseases / genetics
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Metabolic Diseases / metabolism
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Nucleobindins
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Obesity / genetics
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Obesity / metabolism*
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Organ Specificity
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Pancreas / innervation
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Pancreas / metabolism*
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Peripheral Nerves / metabolism
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Polymorphism, Genetic
Substances
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Calcium-Binding Proteins
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DNA-Binding Proteins
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NUCB2 protein, human
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Nerve Tissue Proteins
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Nucleobindins