A squaraine and Hg(2+)-based colorimetric and "turn on" fluorescent probe for cysteine

Qian Lin; Yangwei Huang; Juan Fan; Ruyong Wang; Nanyan Fu

doi:10.1016/j.talanta.2013.04.006

A squaraine and Hg(2+)-based colorimetric and "turn on" fluorescent probe for cysteine

Talanta. 2013 Sep 30:114:66-72. doi: 10.1016/j.talanta.2013.04.006. Epub 2013 Apr 12.

Authors

Qian Lin¹, Yangwei Huang, Juan Fan, Ruyong Wang, Nanyan Fu

Affiliation

¹ Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education, and Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, PR China.

PMID: 23953443
DOI: 10.1016/j.talanta.2013.04.006

Abstract

A novel squaraine derivative (SQ-1) was synthesized and characterized for the determination of cysteine. Binding with Hg(2+) as a fluorescent quencher to SQ-1 leads to absorption and emission turn-off. More significantly, the SQ-1-Hg(2+) complex exhibits a dual-channel chromofluorogenic responses to biologically important cysteine with a high sensitivity and selectivity over other natural amino acids, along with a low detection limit of 36.7 nM.

Keywords: Cysteine; Fluorescent chemosensor; Mercury; Squaraine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Colorimetry
Cyclobutanes / chemistry*
Cysteine / analysis*
Cysteine / chemistry
Fluorescent Dyes / chemistry*
Mercury / analysis
Mercury / chemistry*
Phenols / chemistry*

Substances

Cyclobutanes
Fluorescent Dyes
Phenols
squaraine
Mercury
Cysteine