Anticholinesterase insecticide action at the murine male reproductive system

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5434-6. doi: 10.1016/j.bmcl.2013.07.021. Epub 2013 Jul 19.

Abstract

The present report describes for the first time that anticholinesterase type insecticides specifically inhibit the fatty acid amide hydrolase and/or monoacylglycerol lipase, as secondary target(s), in the murine male reproductive system (testis and epididymis cauda), thereby presumably being involved with spermatotoxicity such as deformity, underdevelopment, and reduced motility.

Keywords: Anticholinesterase insecticides; Chlorpyrifos; Fatty acid amide hydrolase; Monoacylglycerol lipase; Organophosphate and methylcarbamate insecticides; Spermatotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amidohydrolases / antagonists & inhibitors*
  • Animals
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology*
  • Enzyme Activation / drug effects
  • Genital Diseases, Male / chemically induced
  • Insecticides / chemistry
  • Insecticides / pharmacology*
  • Male
  • Mice
  • Molecular Structure
  • Spermatozoa / drug effects*

Substances

  • Cholinesterase Inhibitors
  • Insecticides
  • Amidohydrolases
  • fatty-acid amide hydrolase