The present report describes for the first time that anticholinesterase type insecticides specifically inhibit the fatty acid amide hydrolase and/or monoacylglycerol lipase, as secondary target(s), in the murine male reproductive system (testis and epididymis cauda), thereby presumably being involved with spermatotoxicity such as deformity, underdevelopment, and reduced motility.
Keywords: Anticholinesterase insecticides; Chlorpyrifos; Fatty acid amide hydrolase; Monoacylglycerol lipase; Organophosphate and methylcarbamate insecticides; Spermatotoxicity.
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