[Viral and drug-induced liver damage in children with tuberculosis: prevalence, clinical features]

Eksp Klin Gastroenterol. 2013:(1):38-43.
[Article in Russian]

Abstract

THE AIM OF THE RESEARCH: Improving the effectiveness of diagnostics and treatment of viral and drug-induced lesions of the liver (DILL) at a tuberculosis in children by identifying the frequency of their distribution, peculiarities of diagnostics and clinics.

Materials and methods: We examined 242 children in the age from 2 months to 17 years, the patients with different forms of tuberculosis.

Results: The prevalence of hepatitis in children with tuberculosis: B - 1,2%, C-0.4%, G - 4,6%, TT - 8,7%. DILL was diagnosed in 67.5% of children - TB patients, in 48% of the children with DILL an asymptomatic course of the disease was noted, however, in 54.4% of the children with DILL cytolitic syndrome was expressed (ALT> standards).

Conclusion: The prevalence of viral hepatitis B and C among children with TB is low. The infection with viruses of hepatitis G and TT is more often, but has no significant impact as on the course of tuberculosis, and on the severity of the liver damage. Drug-induced liver damage is a dominant view of pathology of the liver in children - TB patients and is mostly asymptomatic, but with a pronounced cytolitic syndrome.

MeSH terms

  • Adolescent
  • Antitubercular Agents / administration & dosage
  • Antitubercular Agents / adverse effects
  • Antitubercular Agents / therapeutic use
  • Biomarkers / blood
  • Chemical and Drug Induced Liver Injury / complications*
  • Chemical and Drug Induced Liver Injury / diagnosis
  • Chemical and Drug Induced Liver Injury / epidemiology
  • Child
  • Child, Preschool
  • Hepatitis Antigens / blood
  • Hepatitis, Viral, Human / complications*
  • Hepatitis, Viral, Human / diagnosis
  • Hepatitis, Viral, Human / epidemiology
  • Humans
  • Infant
  • Liver / drug effects
  • Liver / pathology
  • Liver Function Tests
  • Moscow
  • Prevalence
  • Tuberculosis / complications*
  • Tuberculosis / diagnosis
  • Tuberculosis / drug therapy
  • Tuberculosis / epidemiology

Substances

  • Antitubercular Agents
  • Biomarkers
  • Hepatitis Antigens