Abstract
Influenza is a major cause of morbidity and mortality. Despite vaccination, many elderly recipients do not develop a protective antibody response. To determine whether Human Leukocyte Antigen (HLA) alleles modulate seroprotection to influenza, a cohort of HLA class II-typed high-risk vaccine recipients was investigated. Haemagglutinin inhibition (HAI) titres were measured 14-40 days post-subunit vaccination. Seroprotection was defined as HAI titres reaching 40 or greater for all three vaccine strains. HLA-DRB1*04∶01 and HLA-DPB1*04∶01 alleles were detected at higher frequencies in seroprotected compared with non-seroprotected individuals. Thus, the presence of certain HLA class II alleles may determine the magnitude of antibody responses to influenza vaccination.
Publication types
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aged
-
Aged, 80 and over
-
Alleles
-
Antibodies, Viral / biosynthesis*
-
Antibodies, Viral / blood
-
Female
-
Gene Expression
-
Gene Frequency
-
HLA-DP beta-Chains / genetics*
-
HLA-DP beta-Chains / immunology
-
HLA-DRB1 Chains / genetics*
-
HLA-DRB1 Chains / immunology
-
Hemagglutination Inhibition Tests
-
Humans
-
Immunity, Active
-
Influenza Vaccines / administration & dosage
-
Influenza Vaccines / immunology*
-
Influenza, Human / blood
-
Influenza, Human / genetics
-
Influenza, Human / immunology
-
Influenza, Human / prevention & control*
-
Male
-
Orthomyxoviridae / immunology*
-
Vaccination*
-
Vaccines, Subunit
Substances
-
Antibodies, Viral
-
HLA-DP beta-Chains
-
HLA-DPB1*04:01 antigen
-
HLA-DRB1 Chains
-
HLA-DRB1*04:01 antigen
-
Influenza Vaccines
-
Vaccines, Subunit
Grants and funding
This study was funded by the UK National Health Service. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.