Abstract
The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.
MeSH terms
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Aminoquinolines / chemistry
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Aminoquinolines / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Down-Regulation / drug effects*
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Drug Screening Assays, Antitumor
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G-Quadruplexes / drug effects*
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Genes, src / drug effects*
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Genes, src / genetics
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Humans
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Ligands
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Molecular Structure
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Neoplasms, Glandular and Epithelial / drug therapy*
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Neoplasms, Glandular and Epithelial / genetics
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Neoplasms, Glandular and Epithelial / pathology
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Photochemical Processes
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Picolinic Acids / chemistry
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Picolinic Acids / pharmacology*
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Structure-Activity Relationship
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Ultraviolet Rays*
Substances
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Aminoquinolines
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Antineoplastic Agents
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Ligands
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Picolinic Acids
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pyridostatin