Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform

Tatsuro Goda; Miyuki Tabata; Mai Sanjoh; Mai Uchimura; Yasuhiko Iwasaki; Yuji Miyahara

doi:10.1039/c3cc44357d

Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platform

Chem Commun (Camb). 2013 Oct 7;49(77):8683-5. doi: 10.1039/c3cc44357d.

Authors

Tatsuro Goda¹, Miyuki Tabata, Mai Sanjoh, Mai Uchimura, Yasuhiko Iwasaki, Yuji Miyahara

Affiliation

¹ Institute of Biomaterial and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda, Tokyo 101-0062, Japan. goda.bsr@tmd.ac.jp miyahara.bsr@tmd.ac.jp.

PMID: 23949309
DOI: 10.1039/c3cc44357d

Abstract

We developed a new building block for a protein- and cell-repellant self-assembled monolayer (SAM) from 2-methacryloyloxyethyl phosphorylcholine (MPC) via a simple Michael-type addition to one mercapto group in alkanedithiol. The thiolated MPC can enable functionalization of a noble metal electrode to minimize noise signal in biosensing.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques / instrumentation*
Cell Adhesion
Electrodes
Equipment Design
Gold / chemistry*
Hep G2 Cells
Humans
Methacrylates / chemistry*
Phosphorylcholine / analogs & derivatives*
Phosphorylcholine / chemistry

Substances

Methacrylates
Phosphorylcholine
2-methacryloyloxyethyl phosphorylcholine
Gold