Role of AIF-1 in the regulation of inflammatory activation and diverse disease processes

Cell Immunol. 2013 Jul-Aug;284(1-2):75-83. doi: 10.1016/j.cellimm.2013.07.008. Epub 2013 Jul 27.

Abstract

Allograft Inflammatory Factor-1 (AIF-1) is a 17kDa cytoplasmic, calcium-binding, inflammation-responsive scaffold protein that is mainly expressed in immunocytes. AIF-1 influences the immune system at several key points and thus modulates inflammatory diseases. AIF-1 boosts the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase (iNOS) and promotes inflammatory cell proliferation and migration. Here we provide an overview of the different pathological processes regulated by AIF-1 mainly including allograft rejection, autoimmune diseases, central nervous system (CNS) injury, vasculopathy and cancer et al.

Keywords: AIF-1; Disease processes; Inflammation; Migration; Proliferation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Base Sequence
  • Calcium-Binding Proteins
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / immunology*
  • Graft Rejection / genetics
  • Graft Rejection / immunology*
  • Humans
  • Inflammation / genetics
  • Inflammation / immunology*
  • Microfilament Proteins
  • Molecular Sequence Data
  • Sequence Alignment

Substances

  • AIF1 protein, human
  • Calcium-Binding Proteins
  • DNA-Binding Proteins
  • Microfilament Proteins