Degraded limonoids and quinoline alkaloids from Dictamnus angustifolius G. Don ex Sweet. and their anti-platelet aggregation activity

Fitoterapia. 2013 Oct:90:209-13. doi: 10.1016/j.fitote.2013.07.023. Epub 2013 Aug 13.

Abstract

A new degraded limonoid, named isodictamdiol A (1), two known degraded limonoids (2, 3) and a new nature product of quinoline alkaloid (4) along with five known quinoline alkaloids (5-9) were isolated from the root bark of Dictamnus angustifolius G. Don ex Sweet.. Certain useful NMR data were generalized to determine the structures of compounds 1 and 4. The structural elucidation of Compound 4 was first reported herein. Compounds 1-9 showed significant inhibitory effects on platelet aggregation induced by ADP at 250 μM, while Compound 4 showed potent anti-platelet aggregation activity.

Keywords: Anti-platelet aggregation activity; Degraded limonoids; Dictamnus angustifolius G. Don ex Sweet.; Quinoline alkaloids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood Platelets / drug effects*
  • Dictamnus / chemistry*
  • Limonins / chemistry
  • Limonins / isolation & purification
  • Limonins / pharmacology*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / chemistry
  • Platelet Aggregation Inhibitors / isolation & purification
  • Platelet Aggregation Inhibitors / pharmacology
  • Quinolines / chemistry
  • Quinolines / isolation & purification
  • Quinolines / pharmacology*
  • Rabbits

Substances

  • Limonins
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • Quinolines
  • isodictamdiol A