Nanoparticles mimicking viral surface topography for enhanced cellular delivery

Adv Mater. 2013 Nov 20;25(43):6233-7. doi: 10.1002/adma.201302737. Epub 2013 Aug 15.

Abstract

Novel silica nanoparticles mimicking virus surface topography are prepared. It is demonstrated that increases in nanoscale surface roughness promote both binding of biomolecules and cellular uptake; thus, the cellular delivery efficiency is significantly increased (scale bars 20 μm).

Keywords: biomimetic synthesis; drug delivery; nanoparticles; surface topography.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Carbocyanines / chemistry
  • Carbocyanines / metabolism
  • Cell Cycle Proteins / antagonists & inhibitors
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Drug Carriers / chemistry*
  • Drug Carriers / toxicity
  • HeLa Cells
  • Humans
  • MCF-7 Cells
  • Microscopy, Confocal
  • Nanoparticles / chemistry*
  • Nanoparticles / toxicity
  • Oligonucleotides / chemistry
  • Oligonucleotides / metabolism
  • Polo-Like Kinase 1
  • Polyethyleneimine / chemistry
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins / metabolism
  • RNA Interference
  • RNA, Small Interfering / metabolism
  • Silicon Dioxide / chemistry*
  • Surface Properties
  • rab GTP-Binding Proteins / antagonists & inhibitors
  • rab GTP-Binding Proteins / genetics
  • rab GTP-Binding Proteins / metabolism

Substances

  • Biocompatible Materials
  • Carbocyanines
  • Cell Cycle Proteins
  • Drug Carriers
  • Oligonucleotides
  • Proto-Oncogene Proteins
  • RAB33A protein, human
  • RNA, Small Interfering
  • cyanine dye 3
  • Silicon Dioxide
  • Polyethyleneimine
  • Protein Serine-Threonine Kinases
  • rab GTP-Binding Proteins