Cu(I)-catalyzed intramolecular oxidative C-H amination of 2-aminoacetophenones: a convenient route toward isatins

Chem Commun (Camb). 2013 Oct 4;49(76):8540-2. doi: 10.1039/c3cc44435j.

Abstract

2-Aminoaryl methyl ketones undergo intramolecular oxidative C-H amination to give the corresponding substituted isatins under an oxygen atmosphere in the presence of [CuI(bpy)]2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetophenones / chemistry*
  • Amination
  • Catalysis
  • Copper / chemistry*
  • Isatin / chemical synthesis*
  • Isatin / chemistry
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Acetophenones
  • 2-aminoacetophenone
  • Copper
  • Isatin