Abstract
Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Candida albicans / drug effects
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Cell Line, Tumor
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Colonic Neoplasms / drug therapy
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Colonic Neoplasms / pathology
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HCT116 Cells
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Humans
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Lung Neoplasms / drug therapy
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Lung Neoplasms / pathology
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Polyenes / chemistry
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Polyenes / isolation & purification
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Polyenes / pharmacology*
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Polymers / chemistry
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Polymers / isolation & purification
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Polymers / pharmacology*
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Republic of Korea
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Spectrum Analysis
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Streptomyces / chemistry*
Substances
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Antifungal Agents
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Antineoplastic Agents
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Polyenes
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Polymers
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polyol