Regulatory interventions are the first line of action used by the U.S. Environmental Protection Agency to fulfill its mission to protect the environment and health. Although the Agency has prioritized the integration of environmental justice into its activities, uncertainty remains in how these considerations will be incorporated into its regulatory decision-making processes. In this article, we examine the emerging practice of Health Impact Assessment and argue for its use within the regulatory assessment paradigm to help answer policy-relevant environmental justice questions. Through the use of a health lens, Health Impact Assessments can lead to a better characterization of the potential impacts and benefits of a rule by introducing novel assessments of potentially significant health effects that would otherwise be excluded, revealing whether the rule is likely to exacerbate inequities or create new ones. This article proposes a framework to overcome analytic barriers in achieving a more comprehensive, equity-focused regulatory analysis.