Abstract
It is unclear whether the genetic background of drug-resistant Pseudomonas aeruginosa was disseminated from a certain clone. Thus, we performed MLST (multilocus sequence typing) of 896 P. aeruginosa isolates that were nonsusceptible to imipenem, meropenem, or ceftazidime. This revealed 254 sequence types (STs), including 104 new STs and 34 STs with novel alleles. Thirty-three clonal complexes and 404 singletons were found. In conclusion, drug-resistant P. aeruginosa clones can be developed from diverse genetic backgrounds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / therapeutic use*
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Carbapenems / therapeutic use*
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Ceftazidime / therapeutic use*
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China / epidemiology
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Genetic Variation*
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Humans
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Multilocus Sequence Typing
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Pseudomonas Infections / drug therapy*
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Pseudomonas Infections / epidemiology
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / drug effects
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Pseudomonas aeruginosa / genetics*
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beta-Lactam Resistance / drug effects
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beta-Lactam Resistance / genetics
Substances
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Anti-Bacterial Agents
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Carbapenems
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Ceftazidime