Abstract
Investigation of the constituents of the whole plant of Hyptis suaveolens led to the isolation of three new abietane diterpenes, isosuaveolic acid (1), 8α,9α-epoxysuaveolic acid (2), and 14-O-methylsuaveolic acid (3), together with eleven known compounds. The structures of 1-3 were established by spectroscopic methods and chemical correlations. Some isolates were tested for their antimycobacterial and cytotoxic activities.
Keywords:
Abietanes; Antimycobacterial activity; Cytotoxic activity; Diterpenes; Hyptis suaveolens.
Copyright © 2013 Verlag Helvetica Chimica Acta AG, Zürich.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abietanes / chemistry*
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Abietanes / pharmacology
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Humans
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Hyptis / chemistry*
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neoplasms / drug therapy
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Plant Preparations / chemistry
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Plant Preparations / pharmacology
Substances
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8,9-epoxy-14-hydroxyabietan-18-oic acid 4a,10a-epoxy-dodecahydro-1-hydroxy-4b,8-dimethyl-2-(1-methylethyl)phenanthrene-8-carboxylic acid
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Abietanes
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Anti-Bacterial Agents
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Antineoplastic Agents
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Plant Preparations