Abietane diterpenes from Hyptis suaveolens

Chem Biodivers. 2013 Aug;10(8):1494-500. doi: 10.1002/cbdv.201200213.

Abstract

Investigation of the constituents of the whole plant of Hyptis suaveolens led to the isolation of three new abietane diterpenes, isosuaveolic acid (1), 8α,9α-epoxysuaveolic acid (2), and 14-O-methylsuaveolic acid (3), together with eleven known compounds. The structures of 1-3 were established by spectroscopic methods and chemical correlations. Some isolates were tested for their antimycobacterial and cytotoxic activities.

Keywords: Abietanes; Antimycobacterial activity; Cytotoxic activity; Diterpenes; Hyptis suaveolens.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abietanes / chemistry*
  • Abietanes / pharmacology
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Humans
  • Hyptis / chemistry*
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Neoplasms / drug therapy
  • Plant Preparations / chemistry
  • Plant Preparations / pharmacology

Substances

  • 8,9-epoxy-14-hydroxyabietan-18-oic acid 4a,10a-epoxy-dodecahydro-1-hydroxy-4b,8-dimethyl-2-(1-methylethyl)phenanthrene-8-carboxylic acid
  • Abietanes
  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Plant Preparations