Cytotoxic ent-kaurane diterpenoids from Isodon nervosus

Chem Biodivers. 2013 Aug;10(8):1487-93. doi: 10.1002/cbdv.201200201.

Abstract

Four new ent-kaurane diterpenoids, rabdonervosins G-J (1-4, resp.), were isolated from the leaves and stems of Isodon nervosus. Their structures were elucidated by extensive spectroscopic analyses, including 1D-, 2D-NMR and HR mass spectra. Compound 2 showed potent cytotoxicity against the HepG2 and PC-9/ZD cell lines with IC50 values of 2.36 and 6.07 μM, respectively, and compound 3 exhibited cytotoxicity against the HepG2 and CNE2 cell lines with IC50 values of 8.64 and 9.77 μM, respectively.

Keywords: Cytotoxic activity; Isodon nervosus; Rabdonervosins G - J; Terpenoids; ent-Kaurane diterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / toxicity
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Diterpenes, Kaurane / chemistry*
  • Diterpenes, Kaurane / toxicity*
  • Humans
  • Inhibitory Concentration 50
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Components, Aerial / chemistry*
  • Plant Extracts / chemistry*
  • Plant Extracts / toxicity*

Substances

  • Antineoplastic Agents
  • Diterpenes, Kaurane
  • Plant Extracts