Downregulation of melanocyte-specific facultative melanogenesis by 4-hydroxy-3-methoxycinnamaldehyde acting as a cAMP antagonist

J Invest Dermatol. 2014 Feb;134(2):551-553. doi: 10.1038/jid.2013.341. Epub 2013 Aug 7.

Authors

Affiliations

¹ College of Pharmacy, Chungbuk National University, Cheongju, Korea.
² New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea.
³ College of Pharmacy, Chungnam National University, Daejeon, Korea.
⁴ College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
⁵ College of Pharmacy, Chungbuk National University, Cheongju, Korea. Electronic address: youngsoo@chungbuk.ac.kr.

PMID: 23934066
DOI: 10.1038/jid.2013.341

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acrolein / analogs & derivatives*
Acrolein / pharmacology
Animals
Cyclic AMP / antagonists & inhibitors*
Down-Regulation / drug effects
Guinea Pigs
Melanins / biosynthesis
Melanins / metabolism*
Melanocytes / drug effects*
Melanocytes / metabolism

Substances

4-methoxycinnamaldehyde
Melanins
Acrolein
Cyclic AMP