Synthesis and study of 1-ethyl-3-carbohydrazide and 3-[1-oxo-2-hydrazino-3-{p-toluenesulfon}]quinolone derivatives against bacterial infections

Eur J Med Chem. 2013 Sep:67:464-8. doi: 10.1016/j.ejmech.2013.06.056. Epub 2013 Jul 9.

Abstract

We have synthesized newer series of quinolone derivatives substituted with hydrazine group (6a-e) and sulfonamide group (7a-e). These compounds were screened for antibacterial activity. All these compounds were fully characterized by spectroscopic means and elemental analysis. From minimum inhibitory concentration (MIC) data, it has been observed that all the synthesized compounds exhibited good antibacterial activity in vitro.

Keywords: Antibacterial; Broad spectrum; Fluoroquinolone; Hydrazine; Quinolone; Sulfonamide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Infections / microbiology*
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects
  • Hydrazines / chemical synthesis
  • Hydrazines / chemistry
  • Hydrazines / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Pseudomonas aeruginosa / drug effects
  • Quinolones / chemical synthesis
  • Quinolones / chemistry
  • Quinolones / pharmacology*
  • Salmonella typhi / drug effects
  • Staphylococcus aureus / drug effects
  • Structure-Activity Relationship

Substances

  • 1-ethyl-3-carbohydrazide
  • 3-(1-oxo-2-hydrazino-3-(p-toluenesulfon))quinolone
  • Anti-Bacterial Agents
  • Hydrazines
  • Quinolones