Nonmotor symptoms in Parkinson's disease: expanding the view of Parkinson's disease beyond a pure motor, pure dopaminergic problem

Victor W Sung; Anthony P Nicholas

doi:10.1016/j.ncl.2013.04.013

Nonmotor symptoms in Parkinson's disease: expanding the view of Parkinson's disease beyond a pure motor, pure dopaminergic problem

Neurol Clin. 2013 Aug;31(3 Suppl):S1-16. doi: 10.1016/j.ncl.2013.04.013. Epub 2013 Jun 14.

Authors

Victor W Sung¹, Anthony P Nicholas

Affiliation

¹ Department of Neurology, University of Alabama at Birmingham and Birmingham VA Medical Center, 1720 7th Avenue South, Birmingham, AL 35294, USA. vsung@uab.edu

PMID: 23931951
DOI: 10.1016/j.ncl.2013.04.013

Abstract

Nonmotor symptoms (NMS) of Parkinson's disease (PD) are critical to identify and treat because of their impact on quality of life. Despite growing evidence of the importance of NMS on patients' quality of life, gaps remain in their recognition and treatment. The result is a need for increased information and understanding of specific NMS and the clinical approaches for their assessment and management in the context of PD as a whole. This article discusses the NMS of PD, their relationship to the pathologic basis of PD, and how NMS can be best managed.

Keywords: Dopaminergic; Motor symptoms; Nonmotor symptoms; Parkinson's disease.

Published by Elsevier Inc.

Publication types

Review

MeSH terms

Animals
Cognition Disorders / diagnosis
Cognition Disorders / drug therapy
Cognition Disorders / psychology
Dopamine / metabolism
Dopamine Agents / therapeutic use*
Humans
Mental Disorders / diagnosis
Mental Disorders / drug therapy
Mental Disorders / psychology
Parkinson Disease / diagnosis*
Parkinson Disease / drug therapy
Parkinson Disease / psychology*
Quality of Life / psychology*
Sleep Wake Disorders / diagnosis
Sleep Wake Disorders / drug therapy
Sleep Wake Disorders / psychology

Substances

Dopamine Agents
Dopamine