Pellagra encephalopathy in the context of alcoholism: review and case report

Alcohol Alcohol. 2014 Jan-Feb;49(1):38-41. doi: 10.1093/alcalc/agt070. Epub 2013 Aug 7.

Abstract

Aims: The aim of the study was to review and describe the Alcoholic Pellagra Encephalopathy, a severe neuropsychiatric condition caused by a combination of niacin (vitamin B3) deficiency and alcohol abuse.

Methods: PsychInfo, Medline and Embase databases were searched for peer-reviewed studies addressing this illness.

Results: A historical and conceptual review of the psychopathological aspects of this condition is offered, followed by the report of a patient with a history of chronic alcohol consumption showing signs of pellagra, delusions and visual hallucinations, which was treated successfully with niacin.

Conclusion: Pellagra encephalopathy should still be considered in the differential diagnosis of acute psychotic disorders seen in the context of chronic alcoholism.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Alcohol Amnestic Disorder / complications*
  • Alcohol Amnestic Disorder / diagnosis*
  • Alcohol Amnestic Disorder / psychology
  • Alcoholism / complications
  • Alcoholism / diagnosis
  • Alcoholism / psychology
  • Diagnosis, Differential
  • Humans
  • Male
  • Middle Aged
  • Pellagra / complications*
  • Pellagra / diagnosis*
  • Pellagra / psychology

Supplementary concepts

  • Alcohol induced encephalopathy