Oxidative stress during development of alcoholic fatty liver: therapeutic potential of cacao polyphenol

Biosci Biotechnol Biochem. 2013;77(8):1792-4. doi: 10.1271/bbb.130380. Epub 2013 Aug 7.

Abstract

The lipid and antioxidative/oxidative profiles of livers from rats fed an ethanol liquid diet for 8 weeks provided evidence for an involvement of oxidative stress (e.g., phospholipid peroxidation) in the development of alcoholic fatty liver (AFL), possibly in an early stage. Cacao polyphenol supplementation produced an ameliorating effect, and may help in AFL prevention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cacao / chemistry
  • Ethanol / administration & dosage
  • Fatty Liver, Alcoholic / drug therapy*
  • Lipid Peroxidation / drug effects*
  • Oxidative Stress / drug effects*
  • Polyphenols / administration & dosage*
  • Polyphenols / chemistry
  • Rats

Substances

  • Polyphenols
  • Ethanol