Abstract
Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3(+) head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemical synthesis
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Antioxidants / chemistry*
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Antioxidants / metabolism
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Calixarenes / chemical synthesis
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Calixarenes / chemistry*
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Calixarenes / metabolism
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Drug Delivery Systems*
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Glutamic Acid / chemical synthesis
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Glutamic Acid / chemistry
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Glutamic Acid / metabolism
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Hydrogen Peroxide / chemical synthesis
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Hydrogen Peroxide / chemistry
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Hydrogen Peroxide / metabolism
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Micelles*
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Molecular Structure
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PC12 Cells
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Phenols / chemical synthesis
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Phenols / chemistry*
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Phenols / metabolism
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Phospholipids / chemical synthesis
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Phospholipids / chemistry*
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Phospholipids / metabolism
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Rats
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Reactive Oxygen Species / metabolism
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Surface-Active Agents / chemical synthesis
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Surface-Active Agents / chemistry
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Surface-Active Agents / metabolism
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Vitamin K 3 / chemical synthesis
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Vitamin K 3 / chemistry
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Vitamin K 3 / metabolism
Substances
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Antioxidants
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Micelles
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Phenols
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Phospholipids
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Reactive Oxygen Species
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Surface-Active Agents
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calix(4)arene
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Calixarenes
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Glutamic Acid
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Vitamin K 3
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Hydrogen Peroxide