Antioxidant phospholipid calix[4]arene mimics as micellular delivery systems

Org Biomol Chem. 2013 Sep 28;11(36):6108-12. doi: 10.1039/c3ob41178h.

Abstract

Amphiphilic calix[4]arenes were designed as phospholipid mimics by incorporating PO3H2 or NMe3(+) head groups. Using PC12 cells and three stressors (H2O2, menadione and glutamate), we established safe calix[4]arene levels that are able not only to deliver antioxidant payloads of curcumin, but intriguingly also have inherent antioxidant properties. The calix[4]arenes appear to be potent synthetic antioxidants that could be used as nano-carriers for drug delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemical synthesis
  • Antioxidants / chemistry*
  • Antioxidants / metabolism
  • Calixarenes / chemical synthesis
  • Calixarenes / chemistry*
  • Calixarenes / metabolism
  • Drug Delivery Systems*
  • Glutamic Acid / chemical synthesis
  • Glutamic Acid / chemistry
  • Glutamic Acid / metabolism
  • Hydrogen Peroxide / chemical synthesis
  • Hydrogen Peroxide / chemistry
  • Hydrogen Peroxide / metabolism
  • Micelles*
  • Molecular Structure
  • PC12 Cells
  • Phenols / chemical synthesis
  • Phenols / chemistry*
  • Phenols / metabolism
  • Phospholipids / chemical synthesis
  • Phospholipids / chemistry*
  • Phospholipids / metabolism
  • Rats
  • Reactive Oxygen Species / metabolism
  • Surface-Active Agents / chemical synthesis
  • Surface-Active Agents / chemistry
  • Surface-Active Agents / metabolism
  • Vitamin K 3 / chemical synthesis
  • Vitamin K 3 / chemistry
  • Vitamin K 3 / metabolism

Substances

  • Antioxidants
  • Micelles
  • Phenols
  • Phospholipids
  • Reactive Oxygen Species
  • Surface-Active Agents
  • calix(4)arene
  • Calixarenes
  • Glutamic Acid
  • Vitamin K 3
  • Hydrogen Peroxide