Standardized drug and pharmacological class network construction

Stud Health Technol Inform. 2013:192:1125.

Abstract

Dozens of drug terminologies and resources capture the drug and/or drug class information, ranging from their coverage and adequacy of representation. No transformative ways are available to link them together in a standard way, which hinders data integration and data representation for drug-related clinical and translational studies. In this paper, we introduce our preliminary work for building a standardized drug and drug class network that integrates multiple drug terminological resources, using Anatomical Therapeutic Chemical (ATC) and National Drug File Reference Terminology (NDF-RT) as network backbone, and expanding with RxNorm and Structured Product Label (SPL). The network consists of 39,728 drugs and drug classes. We calculated and compared structure similarity for each drug/drug class pair from ATC and NDF-RT, and analyzed constructed drug class network from chemical structure perspective.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Drug Information Services / standards*
  • Medical Record Linkage / standards*
  • Natural Language Processing*
  • Pharmaceutical Preparations / standards*
  • RxNorm*
  • Vocabulary, Controlled*

Substances

  • Pharmaceutical Preparations