Novel NGF-potentiating limonoids from the fruits of Melia toosendan

Fitoterapia. 2013 Oct:90:192-8. doi: 10.1016/j.fitote.2013.07.019. Epub 2013 Aug 3.

Abstract

Four new limonoids (1-4), together with five known limonoids (5-9), were isolated from the fruits of Melia toosendan. Their structures were elucidated based on extensive spectroscopic analyses (1D- and 2D-NMR, HRESIMS, IR, [α](D)). The isolated compounds were evaluated for their neurite outgrowth-promoting activities. Compounds 2 and 6 significantly enhanced NGF-mediated neurite outgrowth in PC12 cells at concentrations ranging from 0.1 to 50.0 μM.

Keywords: Limonoid; Melia toosendan; Meliaceae; Neurite outgrowth-promoting activity; Nimbolinin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Fruit
  • Limonins / chemistry
  • Limonins / isolation & purification
  • Limonins / pharmacology*
  • Melia / chemistry*
  • Molecular Structure
  • Nerve Growth Factor / metabolism*
  • Neurites / drug effects
  • PC12 Cells
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Rats

Substances

  • Limonins
  • Plant Extracts
  • Nerve Growth Factor