Abstract
Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Gastrointestinal Tract / diagnostic imaging*
-
Indium / chemistry
-
Lactic Acid / administration & dosage
-
Lactic Acid / chemistry
-
Mice
-
Optical Imaging*
-
Polyglycolic Acid / administration & dosage
-
Polyglycolic Acid / chemistry
-
Polylactic Acid-Polyglycolic Acid Copolymer
-
Quantum Dots / chemistry*
-
Radiography
-
Selenium Compounds / chemistry
-
Sulfides / chemistry
-
Water / chemistry
-
Whole Body Imaging
-
Zinc Compounds / chemistry
Substances
-
Selenium Compounds
-
Sulfides
-
Zinc Compounds
-
Indium
-
Water
-
Polylactic Acid-Polyglycolic Acid Copolymer
-
Polyglycolic Acid
-
Lactic Acid
-
zinc selenide