A Nd:Gd3Ga5O12 (Nd:GGG) laser operating at a wavelength of 1423.4 nm was demonstrated, which has not yet been reported, and is of great interest for wide application potential. With a pumped power of 18.5 W, a maximum output power of 3.63 W was obtained, corresponding to an optical-to-optical efficiency of 19.6% and a slope efficiency of 26%. These unique characteristics of a Nd:GGG laser at 1423.4 nm thereby open new opportunities for a light source in the field of medicine.