Synthesis and SAR studies of praziquantel derivatives with activity against Schistosoma japonicum

Molecules. 2013 Jul 31;18(8):9163-78. doi: 10.3390/molecules18089163.

Abstract

The synthesis and structure-activity relationship (SAR) studies of praziquantel derivatives with activity against adult Schistosoma japonicum are described. Several of them showed better worm killing activity than praziquantel and could serve as leads for further optimization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Molecular Structure
  • Praziquantel / analogs & derivatives
  • Praziquantel / chemical synthesis*
  • Praziquantel / pharmacology
  • Schistosoma japonicum / drug effects*
  • Schistosoma japonicum / pathogenicity
  • Schistosomiasis / drug therapy*
  • Schistosomiasis / parasitology
  • Schistosomicides / administration & dosage
  • Structure-Activity Relationship*

Substances

  • Schistosomicides
  • Praziquantel