Metaplastic mammary carcinoma with discrepant hormone receptor results by IHC and RT-PCR

Oncology (Williston Park). 2013 Jun;27(6):526-7, 566.

Abstract

This is a young premenopausal woman with a T1cN0 metaplastic breast cancer that is ER/PR Allred score 3, but negative by mRNA. Our recommendations are: adjuvant chemotherapy with TAC x 6 or dose-dense doxorubicin and cyclophosphamide followed by paclitaxel (ddAC-T). Whole-breast radiation therapy would follow. The patient could try tamoxifen, although the likelihood of benefit is very small.

Publication types

  • Case Reports

MeSH terms

  • Breast Neoplasms / chemistry*
  • Breast Neoplasms / pathology
  • CA-125 Antigen / blood
  • Female
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Neoplasm Metastasis
  • Receptor, ErbB-2 / analysis*
  • Receptors, Estrogen / analysis*
  • Receptors, Progesterone / analysis*
  • Reverse Transcriptase Polymerase Chain Reaction / methods*

Substances

  • CA-125 Antigen
  • Receptors, Estrogen
  • Receptors, Progesterone
  • ERBB2 protein, human
  • Receptor, ErbB-2