Abstract
This is a young premenopausal woman with a T1cN0 metaplastic breast cancer that is ER/PR Allred score 3, but negative by mRNA. Our recommendations are: adjuvant chemotherapy with TAC x 6 or dose-dense doxorubicin and cyclophosphamide followed by paclitaxel (ddAC-T). Whole-breast radiation therapy would follow. The patient could try tamoxifen, although the likelihood of benefit is very small.
MeSH terms
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Breast Neoplasms / chemistry*
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Breast Neoplasms / pathology
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CA-125 Antigen / blood
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Female
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Humans
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Immunohistochemistry
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Middle Aged
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Neoplasm Metastasis
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Receptor, ErbB-2 / analysis*
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Receptors, Estrogen / analysis*
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Receptors, Progesterone / analysis*
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Reverse Transcriptase Polymerase Chain Reaction / methods*
Substances
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CA-125 Antigen
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Receptors, Estrogen
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Receptors, Progesterone
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ERBB2 protein, human
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Receptor, ErbB-2