Abstract
RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Aptamers, Nucleotide / chemistry
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Base Sequence
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Cell Line, Tumor
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Erythrocyte Membrane / chemistry*
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Erythrocyte Membrane / metabolism
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Flow Cytometry
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Fluorescein-5-isothiocyanate / chemistry
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Folic Acid / chemistry
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Folic Acid / metabolism
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Humans
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Lipids / chemistry*
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Nanoparticles / chemistry*
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Nucleolin
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Phosphoproteins / chemistry
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Phosphoproteins / metabolism
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Polyethylene Glycols / chemistry
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RNA-Binding Proteins / chemistry
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RNA-Binding Proteins / metabolism
Substances
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Aptamers, Nucleotide
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Lipids
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Phosphoproteins
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RNA-Binding Proteins
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Polyethylene Glycols
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Folic Acid
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Fluorescein-5-isothiocyanate