Protein resistance and pH-responsive controlled release from the modification of single-walled carbon nanotubes with a double polymer layer

Macromol Biosci. 2013 Sep;13(9):1259-66. doi: 10.1002/mabi.201300157. Epub 2013 Jul 31.

Abstract

A reliable and easy method is developed to confer protein resistance and drug controlled release dual functions to single-walled carbon nanotubes (SWNTs) by modification with a polydopamine (Pdop) layer and poly(oligo(ethylene glycol) methacrylate) (POEGMA) brushes. The study of protein resistance demonstrates that POEGMA-modified SWNTs exhibit higher protein resistance than pristine SWNTs, and the protein resistance ability is dependant on the length of the POEGMA molecule. Furthermore, the Pdop layer can serve as a pH-responsive switch for controlled loading and release of rhodamine 6G. The integration of protein resistance and pH-responsive controlled release make the double-layer modified SWNTs attractive for drug delivery in cancer therapy.

Keywords: controlled release; pH-responsivity; protein resistance; single-walled carbon nanotubes; surface modification.

MeSH terms

  • Adsorption
  • Animals
  • Cattle
  • Delayed-Action Preparations
  • Hydrogen-Ion Concentration
  • Indoles / chemistry*
  • Methacrylates / chemical synthesis
  • Methacrylates / chemistry*
  • Nanotubes, Carbon / chemistry*
  • Nanotubes, Carbon / ultrastructure
  • Photoelectron Spectroscopy
  • Polyethylene Glycols / chemical synthesis
  • Polyethylene Glycols / chemistry*
  • Polymers / chemistry*
  • Polymethacrylic Acids
  • Rhodamines / metabolism
  • Serum Albumin, Bovine / metabolism*
  • Spectroscopy, Fourier Transform Infrared
  • Spectrum Analysis, Raman
  • Thermogravimetry

Substances

  • Delayed-Action Preparations
  • Indoles
  • Methacrylates
  • Nanotubes, Carbon
  • Polymers
  • Polymethacrylic Acids
  • Rhodamines
  • poly(poly(ethylene glycol)methacrylate)
  • polydopamine
  • rhodamine 6G
  • Serum Albumin, Bovine
  • Polyethylene Glycols