Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

Chem Commun (Camb). 2013 Sep 18;49(72):7959-61. doi: 10.1039/c3cc44627a. Epub 2013 Jul 31.

Abstract

A new rhodamine fluorescent probe for monitoring ˙OH has been developed based on the oxidative C-H abstraction reaction of rhodamine cyclic hydrazide. The probe exhibits excellent selectivity for ˙OH with virtually no interference by other ROS/RNS species. Fluorescent imaging of A549 and RAW264.7 cells is also successfully demonstrated to detect intracellular ˙OH in live cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Cyclization
  • Fluorescence
  • Fluorescent Dyes / chemistry*
  • Humans
  • Hydrazines / chemistry*
  • Hydroxyl Radical / analysis*
  • Hydroxyl Radical / chemistry
  • Limit of Detection
  • Molecular Structure
  • Rhodamines / chemistry*

Substances

  • Fluorescent Dyes
  • Hydrazines
  • Rhodamines
  • Hydroxyl Radical