Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

PLoS One. 2013 Jul 22;8(7):e68294. doi: 10.1371/journal.pone.0068294. Print 2013.

Abstract

The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Antigens, CD / blood
  • Antigens, CD / chemistry
  • Antigens, CD / metabolism*
  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism*
  • Cell Adhesion Molecules / blood
  • Cell Adhesion Molecules / chemistry
  • Cell Adhesion Molecules / metabolism*
  • Child
  • Child, Preschool
  • Female
  • Gene Expression Regulation / immunology
  • Humans
  • Immune Tolerance*
  • Infant
  • Infant, Low Birth Weight / blood
  • Infant, Low Birth Weight / immunology
  • Infant, Newborn
  • Male
  • Meningococcal Infections / complications*
  • Sepsis / blood
  • Sepsis / complications
  • Sepsis / immunology*
  • Sepsis / metabolism*
  • Solubility

Substances

  • Antigens, CD
  • CD66 antigens
  • Cell Adhesion Molecules

Grants and funding

MvdF was supported by a Fellowship of the European Society of Paediatric Infectious Diseases (ESPID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.