Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo

Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9309-12. doi: 10.1002/anie.201304401. Epub 2013 Jul 24.
No abstract available

Keywords: CH activation; cytochromes; enzyme catalysis; protein engineering; synthetic biology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amination
  • Biocatalysis
  • Cytochrome P-450 Enzyme System / chemistry
  • Cytochrome P-450 Enzyme System / metabolism*
  • Molecular Structure
  • Protein Engineering
  • Stereoisomerism
  • Sulfonamides / chemistry
  • Sulfonamides / metabolism*

Substances

  • Sulfonamides
  • beta-sultam
  • Cytochrome P-450 Enzyme System