A sib-pair analysis of impulsivity in bipolar disorder type I

Compr Psychiatry. 2013 Nov;54(8):1148-52. doi: 10.1016/j.comppsych.2013.05.019. Epub 2013 Jul 25.

Abstract

Objective: The aim of this study was to compare impulsivity among patients with bipolar disorder, their siblings, and healthy controls in order to examine whether impulsivity in bipolar disorder is related to genetic liability for the illness.

Methods: Using the Barratt Impulsiveness Scale, we assessed 204 subjects: 67 euthymic outpatients with bipolar disorder type I, 67 siblings without bipolar disorder, and 70 healthy controls.

Results: Impulsivity scores were higher among patients with bipolar disorder than among healthy controls. Siblings showed higher motor impulsivity scores than did healthy controls.

Conclusions: Our results suggest that motor impulsivity may be a vulnerability marker for bipolar disorder. Our data may contribute to further improve preventive strategies in subjects at high risk for bipolar disorder.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers
  • Bipolar Disorder / genetics*
  • Bipolar Disorder / psychology
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Impulsive Behavior / genetics*
  • Impulsive Behavior / psychology
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
  • Siblings / psychology*

Substances

  • Biomarkers