Abstract
Two new steroidal saponins, named drangustosides A-B (1-2), together with eight known compounds were isolated and characterized from the MeOH extract of Dracaena angustifolia Roxb. The structures of compounds were assigned based on 1D and 2D NMR spectroscopic analyses, including HMQC, HMBC, and NOESY. Compounds 1 and 2 showed anti-inflammatory activity by superoxide generation and elastase release by human neutrophils in response to fMLP/CB.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology*
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Cells, Cultured
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Dracaena / chemistry*
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neutrophils / drug effects
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Pancreatic Elastase / antagonists & inhibitors
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Pancreatic Elastase / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology*
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Saponins / chemistry*
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Saponins / pharmacology
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Steroids / chemistry
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Steroids / pharmacology
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Superoxides / chemistry
Substances
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Anti-Inflammatory Agents
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Plant Extracts
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Saponins
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Steroids
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Superoxides
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Pancreatic Elastase