PHIP-label: parahydrogen-induced polarization in propargylglycine-containing synthetic oligopeptides

Chem Commun (Camb). 2013 Sep 14;49(71):7839-41. doi: 10.1039/c3cc43978j.

Abstract

The unsaturated side chain of l-propargylglycine (Pra) was used to study parahydrogen-induced polarization (PHIP) in synthetic oligopeptides. For the first time PHIP-induced NMR signal enhancement was demonstrated using model peptides bearing various functional side chains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Amino Acid Sequence
  • Catalysis
  • Glycine / analogs & derivatives*
  • Glycine / chemistry
  • Hydrogen / chemistry
  • Hydrogenation
  • Magnetic Resonance Spectroscopy
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Sulfhydryl Compounds / chemistry

Substances

  • Alkynes
  • Oligopeptides
  • Sulfhydryl Compounds
  • propargylglycine
  • Hydrogen
  • Glycine