Fluorescent labels in biosensors for pathogen detection

Crit Rev Biotechnol. 2015 Mar;35(1):82-93. doi: 10.3109/07388551.2013.804487. Epub 2013 Jul 25.

Abstract

Infectious diseases caused by pathogens have become a life-threatening problem for millions of people around the world in recent years. Therefore, the need of efficient, fast, low-cost and user-friendly biosensing systems to monitor pathogen has increased enormously in the last few years. This paper presents an overview of different fluorescent labels and the utilization of fluorescence-based biosensor techniques for rapid, direct, sensitive and real-time identification of bacteria. In these biosensors, organic dyes, nanomaterials and rare-earth elements are playing an increasing role in the design of biosensing systems with an interest for applications in bacterial analysis.

Keywords: Carbon nanotube; carbon quantum dot; fluorescence-based biosensor; fluorescent labels; organic dye; pathogen detection; rare-earth elements; semiconductor quantum dots.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria
  • Biosensing Techniques*
  • Fluorescent Dyes*
  • Immunoassay

Substances

  • Fluorescent Dyes