Silver cations fold i-motif at neutral pH

Chem Commun (Camb). 2013 Sep 11;49(70):7696-8. doi: 10.1039/c3cc43495h.

Abstract

i-Motif DNA structures have previously been utilised for many different nanotechnological applications, but all have used acidic conditions to fold the DNA. Herein we describe the use of silver cations to fold an i-motif forming DNA sequence at physiological pH. Subsequent DNA unfolding can be achieved by chelation with cysteine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cations / chemistry
  • Circular Dichroism
  • Cysteine / chemistry
  • DNA / chemistry
  • Hydrogen-Ion Concentration
  • Nucleic Acid Conformation
  • Silver / chemistry*

Substances

  • Cations
  • Silver
  • DNA
  • Cysteine