The vagotomy alleviates the anorectic effect of an excess amount of dietary leucine on rats fed a low-protein diet

Ryoji Yoshimura; Yee Yin Ho; Takafumi Mizushige; Kousaku Ohinata; Ryuhei Kanamoto

doi:10.1271/bbb.130150

The vagotomy alleviates the anorectic effect of an excess amount of dietary leucine on rats fed a low-protein diet

Biosci Biotechnol Biochem. 2013;77(7):1593-4. doi: 10.1271/bbb.130150.

Authors

Ryoji Yoshimura¹, Yee Yin Ho, Takafumi Mizushige, Kousaku Ohinata, Ryuhei Kanamoto

Affiliation

¹ Laboratory of Molecular Nutrition, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan.

PMID: 23877616
DOI: 10.1271/bbb.130150

Abstract

It is well known that large dose of leucine reduces the food intake and causes growth retardation in experimental animals when leucine is given with a low-protein diet. However, the mechanism for the anorectic effect of leucine has not yet been clarified. We demonstrate here that the anorectic effect of leucine was significantly reduced in a vagotomized rat.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Appetite Depressants / pharmacology*
Diet*
Diet, Protein-Restricted / adverse effects*
Leucine / pharmacology*
Male
Rats
Rats, Sprague-Dawley
Vagotomy*

Substances

Appetite Depressants
Leucine