A 76-year-old man with movement disorder had a I-FP-CIT (DaTSCAN) SPECT exam demonstrating universally decreased striatal uptake. It was later determined that he had taken modafinil, and the scintigraphy was interpreted as false positive. Because of progressive symptoms, DaTSCAN was repeated 43 months later, with modafinil withheld for 7 days. Striatal uptake values were nearly doubled compared with the modafinil state and were now above normal upper limit. This suggests pharmacological upregulation of dopamine transport capacity by chronic modafinil treatment. In this setting, I-FP-CIT striatal uptake values should be interpreted with caution.