eRNAs reach the heart of transcription

Cell Res. 2013 Oct;23(10):1151-2. doi: 10.1038/cr.2013.97. Epub 2013 Jul 23.

Abstract

Recently, various studies shed light on the functional significance of enhancer RNAs. Two recent studies published in Nature by Li et al. and Lam et al. highlight the importance of these newly characterized RNA molecules and their key role in controlling transcriptional programs.

Publication types

  • Comment

MeSH terms

  • Animals
  • Down-Regulation / genetics*
  • Enhancer Elements, Genetic / genetics*
  • Estrogens / pharmacology*
  • Humans
  • Macrophages / metabolism*
  • Nuclear Receptor Subfamily 1, Group D, Member 1 / metabolism*
  • RNA, Untranslated / genetics*
  • Transcription, Genetic / genetics*
  • Transcriptional Activation / drug effects*

Substances

  • Estrogens
  • Nuclear Receptor Subfamily 1, Group D, Member 1
  • RNA, Untranslated