Abstract
The experiments on the model of aconitine-induced arrhythmia in anesthetized rats and awake dogs with cardiac rhythm disorders caused by the coronary artery occlusion showed that all four metabolites of bonnecor possessed the antiarrhythmic activity. Metabolite 4 proved to be the most active on both models of cardiac rhythm disorders.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Aconitine
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Animals
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Anti-Arrhythmia Agents / metabolism
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Anti-Arrhythmia Agents / therapeutic use*
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Arrhythmias, Cardiac / drug therapy
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Arrhythmias, Cardiac / etiology
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Dibenzazepines / metabolism
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Dibenzazepines / therapeutic use*
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Dogs
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Drug Evaluation, Preclinical
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Rats
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Time Factors
Substances
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Anti-Arrhythmia Agents
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Dibenzazepines
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tiracizine
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Aconitine